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1994-09-03
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Document 0079
DOCN M9490079
TI Th2-like CD8+ T cells showing B cell helper function and reduced
cytolytic activity in human immunodeficiency virus type 1 infection.
DT 9411
AU Maggi E; Giudizi MG; Biagiotti R; Annunziato F; Manetti R; Piccinni MP;
Parronchi P; Sampognaro S; Giannarini L; Zuccati G; et al; Division of
Clinical Immunology and Allergy, University of; Florence, Italy.
SO J Exp Med. 1994 Aug 1;180(2):489-95. Unique Identifier : AIDSLINE
MED/94321903
AB We analyzed at clonal level the functional profile of circulating or
skin-infiltrating T lymphocytes from two individuals infected with the
human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like
syndrome (eczematous dermatitis, recurrent skin and sinopulmonary
infections, and hypergammaglobulinemia E) and showing virtually no
circulating CD4+ T cells. Most of the CD3+ T cell clones generated from
both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8-
TCR alpha beta + which exhibited reduced mRNA expression for the CD8
molecule or no mRNA expression for either CD4 or CD8 molecules. The
great majority of both CD4- CD8+ and CD4- CD8- did not produce
interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather,
most of them produced large amounts of both interleukin (IL) 4 and IL-5
and provided B cell helper function for IgE synthesis. These data
suggest that a switch of cytolytic CD8+ T cells showing a Th1-like
cytokine secretion profile to cells that make Th2-type cytokines,
exhibit reduced cytolytic potential, and provide B cell helper function
can occur in the course of HIV-1 infection. These cells may contribute
to the reduced defense against viral infections and intracellular
parasites and account for the elevated IgE serum levels, eosinophilia,
and the allergic-like clinical manifestations seen in a proportion of
HIV-1-infected individuals.
DE Antigens, CD4/GENETICS/IMMUNOLOGY Antigens, CD8/GENETICS/IMMUNOLOGY
B-Lymphocytes/*IMMUNOLOGY Clone Cells Cytokines/BIOSYNTHESIS
*Cytotoxicity, Immunologic Human HIV
Infections/COMPLICATIONS/*IMMUNOLOGY HIV-1/*IMMUNOLOGY
Interleukin-4/IMMUNOLOGY Job's Syndrome/COMPLICATIONS/IMMUNOLOGY
Phenotype Support, Non-U.S. Gov't T-Lymphocytes,
Helper-Inducer/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).